Abstract
This 54-year-old man accidentally sprayed himself with the chemical agent glyphosate, a herbicide derived from the amino acid glycine. He developed disseminated skin lesions 6 hours after the accident. One month later, he developed a symmetrical parkinsonian syndrome. Two years after the initial exposure to glyphosate, magnetic resonance imaging revealed hyperintense signal in the globus pallidus and substantia nigra, bilaterally, on T2-weighted images. Levodopa/benserazide 500/125 mg daily provided satisfactory clinical outcome.
MeSH terms
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Antiparkinson Agents / therapeutic use
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Benserazide / therapeutic use
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Drug Therapy, Combination
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Globus Pallidus / pathology
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Glycine / analogs & derivatives
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Glycine / poisoning*
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Glyphosate
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Herbicides / poisoning*
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Humans
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Levodopa / therapeutic use
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Parkinson Disease, Secondary / chemically induced*
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Parkinson Disease, Secondary / drug therapy
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Parkinson Disease, Secondary / pathology*
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Substantia Nigra / pathology
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Videotape Recording
Substances
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Antiparkinson Agents
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Herbicides
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Levodopa
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Benserazide
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Glycine