Aortic pulse wave velocity as a marker of cardiovascular disease in subjects over 70 years old

J Hypertens. 2001 May;19(5):871-7. doi: 10.1097/00004872-200105000-00006.


Background: Aortic pulse wave velocity (PWV) is a significant and independent predictor of cardiovascular diseases (CVD) in hypertensive subjects and in patients with end-stage renal disease, but its contribution to cardiovascular risk in subjects between 70 and 100 years old has never been tested.

Patients: A cohort of 124 subjects (mean age: 87 +/- 7 years) was studied in two geriatric departments in a Paris suburb. Together with sphygmomanometric blood pressure measurements, aortic PWV was measured using a validated automatic device.

Results: Blood pressure, heart rate and body mass index, but not age, explained 48% of the PWV variability in this cohort. Furthermore, PWV was the major factor predicting the presence of CVD. The adjusted odds ratio was 17.44 (95% confidence intervals: 2.52-120.55). Antihypertensive drug therapy and low plasma albumin level had only an additive role. Blood pressure, particularly pulse pressure, had no predictive value.

Conclusion: In 70-100-year-old subjects, aortic PWV is a strong independent marker of CVD, a finding that remains to be to confirmed by long-term longitudinal studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aorta / physiopathology*
  • Blood Flow Velocity*
  • Cardiovascular Diseases / diagnosis*
  • Cardiovascular Diseases / psychology
  • Cohort Studies
  • Dementia / etiology
  • Forecasting
  • Humans
  • Pulse*