Nostocyclamide M: a cyanobacterial cyclic peptide with allelopathic activity from Nostoc 31

Phytochemistry. 2001 Jun;57(4):613-9. doi: 10.1016/s0031-9422(00)00470-2.


A cyclic peptide containing thiazole and oxazole moieties was isolated from Nostoc 31 and its structure determined by chemical degradation detailed NMR and mass spectroscopic analyses. The compound is stereochemically pure and closely related to nostocyclamide in which D-valine is replaced by D-methionine. Therefore, it differs from tenuecyclamide C reported to contain L-methionine. It shows allelopathic activity against Anabaena 7120, but is inactive against grazers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anabaena / drug effects
  • Cyanobacteria / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology
  • Thiazoles / chemistry*


  • Peptides, Cyclic
  • Thiazoles
  • nostocyclamide M