Compartments and cell flows within the mouse haemopoietic system. I. Restricted interchange between haemopoietic sites

Cell Tissue Kinet. 1975 May;8(3):219-32. doi: 10.1111/j.1365-2184.1975.tb01221.x.

Abstract

Two chromosomally distinguishable haemopoietic cell populations were injected into lethally irradiated syngeneic recipients. The presence or absence of the T(14;15)6Ca reciprocal translocation (indicated by T6 marker chromosomes) did not affect the proliferation of a population. Wide disparities were found in the proportions of the two donor cell populations between animals and between the right and left femora of individual animals. This suggest (i) that there is, at most, a very limited interchange of proliferating cells and their precursors between the marrow of different bones; and (ii) that the number of clones proliferating in the bone marrow at any one time must be rather small; there was evidence that this number depended in part on the number of haemopoietic cells injected. Exchange between the mitotically active cell populations of spleen, thymus, lymph nodes and bone marrow was also limited, as shown by significant disparities in the proportions of the two donor populations proliferating in the different tissues of individual mice.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Bone Marrow / radiation effects
  • Bone Marrow Cells
  • Cell Movement*
  • Chromosome Aberrations
  • Clone Cells
  • Femur
  • Hematopoiesis / radiation effects
  • Hematopoietic Stem Cells / radiation effects*
  • Hematopoietic System / physiology
  • Hematopoietic System / radiation effects*
  • Hybrid Cells
  • Lymph Nodes / radiation effects
  • Male
  • Mice
  • Mitosis
  • Radiation Genetics
  • Radiation Injuries, Experimental*
  • Spleen / radiation effects
  • Thymus Gland / radiation effects
  • Translocation, Genetic