Neuropsychological performance of right- and left-frontotemporal dementia compared to Alzheimer's disease

J Int Neuropsychol Soc. 2001 May;7(4):468-80. doi: 10.1017/s1355617701744037.


The performance of 16 patients with Alzheimer's disease (AD) was compared to 11 patients with right-frontotemporal dementia (FTD) and 11 patients with left-FTD on a comprehensive neuropsychological battery. Standardized scores (i.e., z scores based on normal control data) were analyzed for 5 cognitive domains. The results revealed that the AD group displayed significant impairment in visual-constructional ability relative to the two FTD groups; however, no significant difference was found between the groups on memory scores (verbal and nonverbal). Patients with left-FTD scored significantly below patients with AD on the language measures (e.g., word retrieval, verbal semantic memory), and verbal executive ability (phonemic fluency); AD patients did not differ from patients with right-FTD on these measures. Patients with right-FTD exhibited significantly more perseverative behavior than AD patients; AD patients did not differ from left-FTD patients on this parameter. These results indicate that the pattern of neuropsychological performance of AD patients is distinguishable from patients with left and right frontal frontotemporal dementia.

MeSH terms

  • Alzheimer Disease / physiopathology*
  • Apraxias / diagnosis
  • Cognition Disorders / diagnosis*
  • Female
  • Frontal Lobe / physiopathology*
  • Functional Laterality / physiology*
  • Humans
  • Language Disorders / diagnosis
  • Male
  • Memory Disorders / diagnosis
  • Middle Aged
  • Neuropsychological Tests
  • Perceptual Disorders / diagnosis
  • Severity of Illness Index
  • Temporal Lobe / physiopathology*
  • Visual Perception / physiology