Preferential expression of reg I beta gene in human adult pancreas

Biochem Biophys Res Commun. 2001 Jun 15;284(3):729-37. doi: 10.1006/bbrc.2001.5033.


In human pancreas two genes, reg I alpha and reg I beta, have been characterized but only the reg I alpha protein has been isolated from human pancreatic secretion. To examine their respective physiological roles in fetal and adult pancreas we have compared the patterns of gene expression using a specific RT-PCR method. No progressive evolution in the two mRNAs levels was observed during fetal development (16--41 weeks). A discoordinate expression of the two genes was found with a higher level of reg I alpha mRNA in fetus and a higher level of regI beta in adult. In addition, if reg I alpha mRNA level was correlated with the expression of genes encoding exocrine proteins in adults, reg I beta mRNA level presented no correlation with any ductular, endocrine, or exocrine gene expression. In human pancreatic cell lines we showed the only expression of reg I beta gene and protein. All these data suggest that the two reg genes and proteins could play different roles in the pancreas.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Biomarkers / analysis
  • Calcium-Binding Proteins / biosynthesis*
  • Calcium-Binding Proteins / genetics
  • Cell Line
  • Gene Expression Regulation, Developmental
  • Humans
  • In Situ Hybridization
  • Lithostathine
  • Middle Aged
  • Nerve Tissue Proteins*
  • Pancreas / embryology
  • Pancreas / metabolism*
  • RNA, Messenger / biosynthesis
  • Transcription, Genetic


  • Biomarkers
  • Calcium-Binding Proteins
  • Lithostathine
  • Nerve Tissue Proteins
  • REG1A protein, human
  • REG1B protein, human
  • RNA, Messenger