Autoradiographic distribution of adrenomedullin receptors in the rat brain

Eur J Pharmacol. 2001 Jun 8;421(2):R1-2. doi: 10.1016/s0014-2999(01)01021-4.

Abstract

The autoradiographic distribution of putative brain adrenomedullin receptors was investigated using [125I]human adrenomedullin(13-52) as a new radioligand. Specific [125I]human adrenomedullin(13-52) binding sites were very discretely distributed in the rat brain with enrichment seen in the choroid plexus and linings of the third, fourth and lateral ventricles, basolateral amygdaloid nuclei, neural lobe of the pituitary gland, the trigeminal nerves and in the granular cell layer of the cerebellum. To our knowledge, this is the first report on the discrete localization of adrenomedullin receptors in the mammalian brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenomedullin
  • Animals
  • Autoradiography
  • Binding, Competitive
  • Brain / metabolism*
  • Iodine Radioisotopes
  • Male
  • Peptide Fragments / metabolism
  • Radioligand Assay
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Adrenomedullin
  • Receptors, Peptide / metabolism*

Substances

  • Iodine Radioisotopes
  • Peptide Fragments
  • Receptors, Adrenomedullin
  • Receptors, Peptide
  • adrenomedullin (13-52)
  • Adrenomedullin