Review
doi: 10.1016/s0959-4388(00)00217-8.
NMDA receptor-mediated dendritic spikes and coincident signal amplification
Affiliations
- PMID: 11399433
- DOI: 10.1016/s0959-4388(00)00217-8
Item in Clipboard
Review
NMDA receptor-mediated dendritic spikes and coincident signal amplification
Curr Opin Neurobiol.
2001 Jun.
Abstract
Dendrites of cortical neurons possess active conductances, which contribute to the nonlinear processing of synaptic information. Recently it has been shown that basal dendrites can generate highly localized spikes mediated by NMDA receptor channels. These spikes may serve as a powerful mechanism to detect and amplify synchronously activated spatially clustered excitatory synaptic inputs in individual dendritic segments, and may enable parallel processing in several integrative dendritic subunits.
Similar articles
-
Ca(2+) signaling in dendritic spines.Curr Opin Neurobiol. 2001 Jun;11(3):349-56. doi: 10.1016/s0959-4388(00)00218-x. Curr Opin Neurobiol. 2001. PMID: 11399434 Review.
-
A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons.J Neurophysiol. 1992 Dec;68(6):2248-59. doi: 10.1152/jn.1992.68.6.2248. J Neurophysiol. 1992. PMID: 1337105 Free PMC article.
-
Adenosine receptor blockade reveals N-methyl-D-aspartate receptor- and voltage-sensitive dendritic spikes in rat hippocampal CA1 pyramidal cells in vitro.Neuroscience. 2000;100(1):21-31. doi: 10.1016/s0306-4522(00)00249-9. Neuroscience. 2000. PMID: 10996455
-
A role for synaptic inputs at distal dendrites: instructive signals for hippocampal long-term plasticity.Neuron. 2007 Dec 6;56(5):866-79. doi: 10.1016/j.neuron.2007.10.020. Neuron. 2007. PMID: 18054862 Free PMC article.
-
Control of Na+ spike backpropagation by intracellular signaling in the pyramidal neuron dendrites.Mol Neurobiol. 2000 Aug-Dec;22(1-3):129-41. doi: 10.1385/MN:22:1-3:129. Mol Neurobiol. 2000. PMID: 11414276 Review.
Cited by
-
Investigations into the involvement of NMDA mechanisms in recognition memory.Neuropharmacology. 2013 Nov;74:41-7. doi: 10.1016/j.neuropharm.2013.04.013. Epub 2013 May 9. Neuropharmacology. 2013. PMID: 23665343 Free PMC article. Review.
-
Nonlinear dendritic processing determines angular tuning of barrel cortex neurons in vivo.Nature. 2012 Oct 18;490(7420):397-401. doi: 10.1038/nature11451. Epub 2012 Sep 2. Nature. 2012. PMID: 22940864
-
Endogenous alkaline transients boost postsynaptic NMDA receptor responses in hippocampal CA1 pyramidal neurons.J Neurosci. 2007 Jul 11;27(28):7438-46. doi: 10.1523/JNEUROSCI.2304-07.2007. J Neurosci. 2007. PMID: 17626204 Free PMC article.
-
Sodium Dynamics in Pyramidal Neuron Dendritic Spines: Synaptically Evoked Entry Predominantly through AMPA Receptors and Removal by Diffusion.J Neurosci. 2017 Oct 11;37(41):9964-9976. doi: 10.1523/JNEUROSCI.1758-17.2017. Epub 2017 Sep 13. J Neurosci. 2017. PMID: 28904093 Free PMC article.
-
Submillisecond precision of the input-output transformation function mediated by fast sodium dendritic spikes in basal dendrites of CA1 pyramidal neurons.J Neurosci. 2003 Aug 27;23(21):7750-8. doi: 10.1523/JNEUROSCI.23-21-07750.2003. J Neurosci. 2003. PMID: 12944503 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
