Cost prediction models for the comparison of two groups

Health Econ. 2001 Jun;10(4):363-6. doi: 10.1002/hec.615.


For trial-based economic evaluation where patient-specific cost data are not routinely available, cost prediction models are commonly used to estimate total cost for each patient. Typically, multiple regression techniques are used on data from diagnosis-matched, non-trial patients (where patient-level cost data are available) to model cost as a function of covariates that are observed on the trial subjects (e.g. length of hospital stay, procedures, etc.). The estimated beta coefficients provide a means of estimating the total cost for each patient in the trial. However, the variability of the beta coefficients due the measurement and sampling error is seldom included in the overall variance expression for mean costs by treatment group. In this paper we provide a method for estimating this variance and provide an example application

Publication types

  • Comparative Study

MeSH terms

  • Angina, Unstable / drug therapy
  • Anticoagulants / economics
  • Anticoagulants / therapeutic use
  • Cost-Benefit Analysis*
  • Drug Costs / statistics & numerical data
  • Enoxaparin / economics
  • Enoxaparin / therapeutic use
  • Hospital Costs / statistics & numerical data*
  • Humans
  • Least-Squares Analysis
  • Middle Aged
  • Models, Econometric*
  • Myocardial Infarction / drug therapy
  • Ontario
  • Outcome Assessment, Health Care
  • Randomized Controlled Trials as Topic / economics*


  • Anticoagulants
  • Enoxaparin