Combined topical flucytosine and amphotericin B for refractory vaginal Candida glabrata infections

Sex Transm Infect. 2001 Jun;77(3):212-3. doi: 10.1136/sti.77.3.212.


Patients with vaginitis due to highly azole resistant Candida glabrata can be particularly difficult to treat. We describe three cases of longstanding vaginal candidiasis due to C glabrata. These had failed to respond to local and systemic antifungals. Flucytosine (1 g) and amphotericin B (100 mg) formulated in lubricating jelly base in a total 8 g delivered dose, was used per vagina once daily for 14 days with significant improvement, both clinically and microbiologically.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amphotericin B / administration & dosage*
  • Antifungal Agents / administration & dosage*
  • Candidiasis, Vulvovaginal / drug therapy*
  • Candidiasis, Vulvovaginal / microbiology
  • Drug Combinations
  • Female
  • Flucytosine / administration & dosage*
  • Humans
  • Middle Aged


  • Antifungal Agents
  • Drug Combinations
  • Amphotericin B
  • Flucytosine