The mammalian Jun proteins: redundancy and specificity

Oncogene. 2001 Apr 30;20(19):2378-89. doi: 10.1038/sj.onc.1204381.


The AP-1 transcription factor is composed of a mixture of homo- and hetero-dimers formed between Jun and Fos proteins. The different Jun and Fos family members vary significantly in their relative abundance and their interactions with additional proteins generating a complex network of transcriptional regulators. Thus, the functional activity of AP-1 in any given cell depends on the relative amount of specific Jun/Fos proteins which are expressed, as well as other potential interacting proteins. This diversity of AP-1 components has complicated our understanding of AP-1 function and resulted in a paucity of information about the precise role of individual AP-1 members in distinct cellular processes. We shall discuss recent studies which suggest that different Jun and Fos family members may have both opposite and overlapping functions in cellular proliferation and cell fate.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis
  • Cell Cycle
  • Cell Transformation, Neoplastic
  • Mitosis
  • Molecular Sequence Data
  • Proto-Oncogene Proteins c-jun / genetics
  • Proto-Oncogene Proteins c-jun / physiology*
  • Proto-Oncogene Proteins p21(ras) / physiology
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Transcription Factor AP-1 / physiology


  • Proto-Oncogene Proteins c-jun
  • Transcription Factor AP-1
  • Proto-Oncogene Proteins p21(ras)