A thioester ligation approach to amphipathic bicyclic peptide library

Org Lett. 2001 May 31;3(11):1681-4. doi: 10.1021/ol015889i.

Abstract

An efficient approach to synthesize an amphipathic bicyclic peptide library from unprotected peptides is demonstrated through an on-resin intramolecular thioester ligation and an off-resin DMSO-mediated disulfide formation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Bridged Bicyclo Compounds / chemical synthesis*
  • Chromatography, High Pressure Liquid
  • Cyclization
  • Molecular Sequence Data
  • Oxidation-Reduction
  • Peptide Library
  • Peptides / chemical synthesis*
  • Sulfhydryl Compounds / chemistry

Substances

  • Bridged Bicyclo Compounds
  • Peptide Library
  • Peptides
  • Sulfhydryl Compounds