Abstract
An efficient approach to synthesize an amphipathic bicyclic peptide library from unprotected peptides is demonstrated through an on-resin intramolecular thioester ligation and an off-resin DMSO-mediated disulfide formation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Bridged Bicyclo Compounds / chemical synthesis*
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Chromatography, High Pressure Liquid
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Cyclization
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Molecular Sequence Data
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Oxidation-Reduction
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Peptide Library
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Peptides / chemical synthesis*
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Sulfhydryl Compounds / chemistry
Substances
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Bridged Bicyclo Compounds
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Peptide Library
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Peptides
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Sulfhydryl Compounds