Phosphoinositide 3-kinases in T lymphocyte activation

Curr Opin Immunol. 2001 Jun;13(3):332-8. doi: 10.1016/s0952-7915(00)00223-5.


Biochemical experiments have established that the metabolism of inositol phospholipids by phosphoinositide 3-kinases (PI3Ks) and lipid-phosphatases is triggered by many receptors that control T lymphocyte function, including antigen-receptors, costimulatory molecules, cytokines and chemokines. Novel effectors of PI3K have been identified in the immune system and shown to be important in the control of lymphocyte activation. Moreover, key lipid-phosphatases have been identified that act to terminate or modulate PI3K signalling in cells of the immune system.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Lymphocyte Activation*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphatidylinositol 3-Kinases / physiology
  • Signal Transduction / immunology
  • T-Lymphocytes / enzymology*
  • T-Lymphocytes / immunology*


  • Phosphatidylinositol 3-Kinases