Studies on the antidiarrhoeal effect of dragon's blood from Croton urucurana

Phytother Res. 2001 Jun;15(4):319-22. doi: 10.1002/ptr.728.


The red sap obtained by slashing the bark of Croton urucurana Baill. (Euphorbiaceae), also known as dragon's blood, was screened for a possible antidiarrhoeal activity on castor oil-induced diarrhoea in rats, cholera toxin-induced intestinal secretion in mice and on small intestinal transit in mice. Dragon's blood at an oral dose of 600 mg/kg caused in marked inhibition of the diarrhoeal response following castor oil administration as well as the intestinal fluid accumulation promoted by cholera toxin. At a similar dose the red sap significantly inhibited the small intestinal transit which was, however, found to be independent of the opioid mechanism. These results suggest a potential usefulness of the red sap from Croton urucurana Baill. in the control of secretory diarrhoea associated pathologies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antidiarrheals / pharmacology*
  • Antidiarrheals / therapeutic use*
  • Castor Oil
  • Cholera Toxin
  • Diarrhea / chemically induced
  • Diarrhea / prevention & control*
  • Euphorbiaceae*
  • Gastrointestinal Motility / drug effects*
  • Male
  • Mice
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plants, Medicinal*
  • Rats
  • Rats, Wistar


  • Antidiarrheals
  • Plant Extracts
  • Castor Oil
  • Cholera Toxin