Integration of the pRB and p53 cell cycle control pathways

J Neurooncol. 2001 Feb;51(3):183-204. doi: 10.1023/a:1010615822317.


Two fundamental molecular pathways, the pRB and p53 pathways, regulate cell growth and cell death. The importance of these pathways in cellular growth control is underscored by the observation that members of these pathways are found mutated in all human cancers. These two pathways have typically been studied and described independently. However, as we discuss here, recent data have revealed an intimate molecular and genetic interaction between the p53 and pRB pathways.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Death / genetics
  • Cell Division / genetics
  • Chromosome Mapping
  • Humans
  • Retinoblastoma Protein / physiology*
  • Tumor Suppressor Protein p53 / physiology*


  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53