Autochthonous mouse models for prostate cancer: past, present and future

Semin Cancer Biol. 2001 Jun;11(3):245-60. doi: 10.1006/scbi.2001.0373.


Prostate cancer continues to be the second leading cancer related death among men. In order to more fully develop effective prevention and intervention strategies for this prevalent disease, the underlying molecular mechanisms of initiation, progression and metastatic spread must be understood. To this end mouse models have an essential role in prostate cancer research in that they can closely mimic the pathological and biochemical features of the disease. In this review we discuss the history of autochthonous murine models of prostate cancer, the essentials of the idealized mouse model for prostate cancer and speculate on approaches towards this goal.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor
  • Cell Compartmentation
  • Disease Models, Animal*
  • Disease Progression
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Mice
  • Mice, Knockout
  • Prostate / pathology
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / immunology
  • Prostatic Neoplasms / pathology*


  • Biomarkers, Tumor