Lens epithelial cell outgrowth on 3 types of intraocular lenses

J Cataract Refract Surg. 2001 Jun;27(6):850-4. doi: 10.1016/s0886-3350(00)00861-0.


Purpose: To compare the outgrowth of lens epithelial cells (LECs) on 3 types of intraocular lenses (IOLs) to determine the influence of lens material and lens design (optic edge) on this phenomenon.

Setting: Department of Ophthalmology, University of Vienna, Medical School, Vienna, Austria.

Method: Ninety eyes scheduled for cataract surgery were included in a prospective comparative study. A standardized surgical procedure was performed by 1 experienced surgeon. Patients received 1 of 3 types of posterior chamber IOLs of similar design with a 6.0 mm optic and poly(methyl methacrylate) haptic: AcrySof (Alcon), HydroView (Bausch & Lomb), or Sensar (Allergan). Each IOL type was implanted in 30 eyes. Postoperative biomicroscopic examinations were performed 1, 3, 7, 30, 90, and 180 days and 1 year after surgery. Lens epithelial cells in each quadrant of the anterior lens surface were subjectively graded. The product with the highest density and the number of quadrants with this density were used to measure LEC outgrowth.

Results: Statistically significant differences (P <.05) were seen between the hydrophilic IOL and the 2 hydrophobic lenses from day 30 until the final examination. The HydroView lens had a higher number of LECs on its anterior surface than the AcrySof or Sensar IOL. There were no statistically significant differences between the 2 acrylic IOLs at any measurement.

Conclusion: The findings suggest that lens surface properties have a greater influence on LEC outgrowth than lens design (ie, sharp optic edge).

Publication types

  • Comparative Study

MeSH terms

  • Acrylic Resins
  • Capsulorhexis
  • Epithelial Cells / pathology*
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Lens, Crystalline / pathology*
  • Lenses, Intraocular*
  • Phacoemulsification / adverse effects*
  • Postoperative Complications / pathology*
  • Prospective Studies
  • Prosthesis Design
  • Surface Properties


  • Acrylic Resins
  • Hydrogel, Polyethylene Glycol Dimethacrylate