Cyclooxygenase-2 expression in normal ovaries and epithelial ovarian neoplasms

Int J Mol Med. 2001 Jul;8(1):31-6. doi: 10.3892/ijmm.8.1.31.

Abstract

Cyclooxygenase-2 (COX-2) expression was investigated immunohistochemically in 57 epithelial ovarian neoplasms and in histologically normal ovaries. Positive immunostaining for COX-2 was observed in 78.6% (22/28) of the ovarian cancers and in 66.7% (14/21) of the borderline-malignant tumors. The rate of expression was significantly higher among the ovarian cancers than the benign cystadenomas (4/8; 50%) (p<0.05). There was a significant correlation between vascular endothelial growth factor (VEGF) expression and microvessel count (MVC), but no correlation between COX-2 expression and MVC. There was a significant correlation between VEGF expression and COX-2 expression in all of the ovarian neoplasms as a whole (p<0.05). These findings suggest that an increase in COX-2 expression may be associated with malignant transformation and tumorigenesis of epithelial ovarian neoplasms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Vessels / enzymology
  • Cyclooxygenase 2
  • Endothelial Growth Factors / biosynthesis
  • Female
  • Humans
  • Immunohistochemistry
  • Isoenzymes / biosynthesis*
  • Lymph Nodes / enzymology
  • Lymph Nodes / pathology
  • Lymphatic Metastasis
  • Lymphokines / biosynthesis
  • Membrane Proteins
  • Omentum / enzymology
  • Omentum / pathology
  • Ovarian Neoplasms / enzymology*
  • Ovarian Neoplasms / metabolism
  • Ovarian Neoplasms / pathology
  • Ovary / chemistry
  • Ovary / enzymology*
  • Peritoneal Neoplasms / enzymology
  • Peritoneal Neoplasms / secondary
  • Prostaglandin-Endoperoxide Synthases / biosynthesis*
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Endothelial Growth Factors
  • Isoenzymes
  • Lymphokines
  • Membrane Proteins
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases