Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives

Farmaco. 2001 Mar;56(3):233-7. doi: 10.1016/s0014-827x(01)01037-0.

Abstract

A series of 3-pyridazinones carrying morpholino, arylpiperidino and arylpiperazino moiety in the position 6 IIa-g were synthesized and evaluated for antinociceptive activity. In the modified Koster test in mice 4-(4-fluorophenyl) piperazine, IIf, was found the most active compound. All the compounds except IId were more active than aspirin in the antinociceptive activity test.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics, Non-Narcotic / chemical synthesis*
  • Analgesics, Non-Narcotic / pharmacology
  • Animals
  • Female
  • Magnetic Resonance Spectroscopy
  • Male
  • Mice
  • Pain Measurement
  • Pyridazines / chemical synthesis*
  • Pyridazines / pharmacology
  • Spectrophotometry, Infrared

Substances

  • Analgesics, Non-Narcotic
  • Pyridazines