A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions

Ann Neurol. 2001 Jun;49(6):793-6. doi: 10.1002/ana.1053.


Severe tissue destruction is the presumed histopathological correlate of hypointense multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity over time with initial histopathological features in 14 biopsied MS lesions. The extent of hypointensity increased in initially demyelinated plaques and decreased in remyelinating lesions. The initial axonal loss determined the increase of hypointensity over time. In conclusion, both axonal loss and demyelinating activity determine the evolution of hypointensity over time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Axons / pathology
  • Biopsy
  • Female
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Multiple Sclerosis / pathology*
  • Time Factors