Disposition of suprofen enantiomers in the cat

Vet J. 2001 Jul;162(1):38-43. doi: 10.1053/tvjl.2001.0584.


Suprofen (SPF) is a non-steroidal anti-inflammatory drug (NSAID), which belongs to the 2-arylpropionic acids subclass. As a result of their chiral characteristics, these compounds have shown a marked enantioselective behaviour with a high degree of interspecies variation. They are mainly eliminated by glucuronidation. Plasma, biliary and urine disposition of SPF was investigated in the cat after intravenous administration of the racemate (dose 2 mg/kg). Both enantiomers exhibited similar disposition profiles in plasma with no evidence of chiral inversion. During bile sampling time, recovered acylglucuronides of R (-) and S (+) SPF were less than 1% of the total dose administered. Only free SPF was recovered in the urine, representing 0.12% of the administered racemic SPF dose. The results indicate that neither chiral inversion nor glucuronidation predominate in SPF disposition in cats.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / blood
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics*
  • Anti-Inflammatory Agents, Non-Steroidal / urine
  • Bile / metabolism
  • Cats / metabolism*
  • Isomerism
  • Male
  • Species Specificity
  • Suprofen / blood
  • Suprofen / pharmacokinetics*
  • Suprofen / urine


  • Anti-Inflammatory Agents, Non-Steroidal
  • Suprofen