Human natriuretic peptides exhibit antimicrobial activity

Eur J Med Res. 2001 May 29;6(5):215-8.

Abstract

Here we describe a novel function for members of the well-characterized human natriuretic peptide family. Human "brain-type natriuretic peptide" (hBNP-32) as well as other members of this peptide class are antimicrobially active against Gram-positive and Gram-negative bacteria and yeast in a dose-dependent manner. This activity of natriuretic peptides is comparable to that of known antimicrobial peptides such as casocidins or magainins.

MeSH terms

  • Animals
  • Anti-Bacterial Agents
  • Anti-Infective Agents / pharmacology*
  • Atrial Natriuretic Factor / pharmacology
  • Bacillus subtilis / drug effects*
  • Humans
  • Microbial Sensitivity Tests
  • Natriuretic Peptide, Brain / pharmacology*
  • Peptide Fragments / pharmacology
  • Pseudomonas aeruginosa / drug effects*
  • Saccharomyces cerevisiae / drug effects*
  • Staphylococcus / drug effects*

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Peptide Fragments
  • Natriuretic Peptide, Brain
  • Ularitide
  • Atrial Natriuretic Factor