Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer

Oncol Rep. Jul-Aug 2001;8(4):763-6. doi: 10.3892/or.8.4.763.


Solid tumors require neovascularization for growth and metastasis. Angiogenesis depends on the local balance between various molecules that induce and inhibit neovascularization. Thrombospondin-1 (TSP-1) is thought to be an antiangiogenic factor. In this study, we examined the correlation between expression of TSP-1 and tumor vascularity, and determined its prognostic significance in colon cancer. Microvessel density, determined by immunostaining for factor VIII-related antigen, was significantly higher in tumors that were TSP-1-negative. TSP-1 expression was inversely correlated with prognosis. Patients with TSP-1-negative tumors had a significantly worse prognosis than did those with TSP-1-positive tumors. Frequency of hepatic recurrence was significantly higher in patients with tumors that were TSP-1-negative. In conclusion, TSP-1 is an important negative-regulator of tumor angiogenesis, and TSP-1 may be useful for predicting recurrence in patients with colon cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / blood supply*
  • Adenocarcinoma / metabolism
  • Adenocarcinoma / pathology
  • Adult
  • Aged
  • Colonic Neoplasms / blood supply*
  • Colonic Neoplasms / metabolism
  • Colonic Neoplasms / pathology
  • Disease-Free Survival
  • Endothelial Growth Factors
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / pathology
  • Factor VIII / metabolism
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Liver Neoplasms / secondary*
  • Lymph Nodes / metabolism
  • Lymph Nodes / pathology
  • Lymphatic Metastasis
  • Lymphokines
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local
  • Neovascularization, Pathologic / metabolism*
  • Neovascularization, Pathologic / pathology
  • Peritoneal Neoplasms / secondary*
  • Prognosis
  • Thrombospondin 1 / metabolism*
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors


  • Endothelial Growth Factors
  • Lymphokines
  • Thrombospondin 1
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Factor VIII