Automatic quantitation of localized in vivo 1H spectra with LCModel

NMR Biomed. 2001 Jun;14(4):260-4. doi: 10.1002/nbm.698.


The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model in vitro spectra from individual metabolite solutions. Complete model spectra, rather than individual resonances, are used in order to incorporate maximum prior information into the analysis. A nearly model-free constrained regularization method automatically accounts for the baseline and lineshape in vivo without imposing a restrictive parameterized form on them. LCModel is automatic (non-interactive) with no subjective input. Approximately maximum-likelihood estimates of the metabolite concentrations and their uncertainties (Cramér-Rao lower bounds) are obtained. LCModel analyses of spectra from users with fields from 1.5 to 9.4 T and a wide range of sequences, particularly with short TE, are used here to illustrate the capabilities and limitations of LCModel and proton MRS.

MeSH terms

  • Algorithms
  • Animals
  • Brain Chemistry
  • Humans
  • Magnetic Resonance Spectroscopy*
  • Rats
  • Signal Processing, Computer-Assisted*
  • Software*