The roles of PPARs in adipocyte differentiation

Prog Lipid Res. 2001 Jul;40(4):269-81. doi: 10.1016/s0163-7827(01)00005-4.

Abstract

Adipose tissue development takes place primarily around birth but adipose cell number can increase throughout life in response to nutritional changes. At the molecular level, adipogenesis is the result of transcriptional remodeling that leads to activation of a considerable number of genes. Several transcription factors act cooperatively and sequentially in this process. This article attempts to review the roles of peroxisome proliferator-activated receptors gamma and delta in the control of preadipocyte proliferation and differentiation during adipose tissue development or during the adaptive response of adipose tissue mass to high-fat feeding.

Publication types

  • Review

MeSH terms

  • Adipocytes / metabolism*
  • Adipocytes / physiology*
  • Adipose Tissue / metabolism*
  • Animals
  • CCAAT-Enhancer-Binding Proteins / metabolism
  • Cell Differentiation
  • Cells, Cultured
  • Fatty Acids / metabolism
  • Humans
  • Insulin / metabolism
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Signal Transduction / physiology*
  • Transcription Factors / physiology*
  • Transcription, Genetic

Substances

  • CCAAT-Enhancer-Binding Proteins
  • Fatty Acids
  • Insulin
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors