Meiotic recombination: breaking the genome to save it

Curr Biol. 2001 Apr 3;11(7):R253-6. doi: 10.1016/s0960-9822(01)00131-2.

Abstract

Recombination ensures the correct segregation of chromosomes to gametes during meiosis. Recent studies point to a universal mechanism for initiating meiotic recombination: the formation of double-strand DNA breaks by Spo11p.

MeSH terms

  • Animals
  • Arabidopsis / cytology
  • Arabidopsis / genetics
  • Chromatin / physiology
  • Chromosome Segregation / genetics
  • DNA / genetics
  • DNA / metabolism
  • Endodeoxyribonucleases
  • Esterases / genetics
  • Esterases / metabolism
  • Meiosis* / genetics
  • Meiosis* / physiology
  • Mice
  • Models, Genetic
  • Mutation
  • Recombination, Genetic*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism

Substances

  • Chromatin
  • DNA
  • Endodeoxyribonucleases
  • Esterases
  • meiotic recombination protein SPO11