Phylogenetic reconstruction of intrapatient evolution of human immunodeficiency virus type 1: predominance of drift and purifying selection

J Gen Virol. 2001 Jul;82(Pt 7):1621-1627. doi: 10.1099/0022-1317-82-7-1621.


The intra-host evolution of 73 human immunodeficiency virus type 1 quasispecies was analysed by split decomposition analysis. Non-synonymous and synonymous nucleotide substitutions were counted along the shortest path connecting all sequences and compared with the numbers expected under the assumption of a random model of mutation. For the majority of substitutions, drift and negative selection seemed to prevail.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Evolution
  • Gene Frequency
  • Genes, env
  • Genes, gag
  • Genes, nef
  • HIV Infections / virology*
  • HIV-1 / genetics*
  • Humans
  • Time Factors