Synthesis and antimicrobial activity of some new 2-phenyl-N-substituted carboxamido-1H-benzimidazole derivatives

H Göker; M Tunçbilek; S Süzen; C Kus; N Altanlar

doi:10.1002/1521-4184(200105)334:5<148::aid-ardp148>3.0.co;2-s

Synthesis and antimicrobial activity of some new 2-phenyl-N-substituted carboxamido-1H-benzimidazole derivatives

Arch Pharm (Weinheim). 2001 May;334(5):148-52. doi: 10.1002/1521-4184(200105)334:5<148::aid-ardp148>3.0.co;2-s.

Authors

H Göker¹, M Tunçbilek, S Süzen, C Kus, N Altanlar

Affiliation

¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey. goker@pharmacy.ankara.edu.tr

PMID: 11413819
DOI: 10.1002/1521-4184(200105)334:5<148::aid-ardp148>3.0.co;2-s

Abstract

Some 1H-benzimidazole-carboxamide derivatives were prepared and their antimicrobial activities against Staphyloccus aureus, Escherichia coli and Candida albicans evaluated. Compounds 18, 22, and 25 exhibited the best activity against Candida albicans.

MeSH terms

Anti-Bacterial Agents
Anti-Infective Agents / chemical synthesis*
Anti-Infective Agents / chemistry
Anti-Infective Agents / pharmacology
Benzimidazoles / chemical synthesis
Benzimidazoles / chemistry
Benzimidazoles / pharmacology*
Candida albicans / drug effects
Combinatorial Chemistry Techniques
Escherichia coli / drug effects
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Anti-Infective Agents
Benzimidazoles