Effect of omeprazole on the pharmacokinetics of sustained-release carbamazepine in healthy male volunteers

Methods Find Exp Clin Pharmacol. Jan-Feb 2001;23(1):37-9. doi: 10.1358/mf.2001.23.1.619178.

Abstract

The present study shows the effect of omeprazole administration on the pharmacokinetics of a sustained-release preparation of carbamazepine in healthy male volunteers. Multiple dose administration of omeprazole increased the Cmax, AUC0-infinity and elimination half life (t1/2e) of carbamazepine. The results suggest that drug monitoring should be carried out when carbamazepine is coadministered with omeprazole.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Anti-Ulcer Agents / pharmacology*
  • Anticonvulsants / blood
  • Anticonvulsants / pharmacokinetics*
  • Area Under Curve
  • Carbamazepine / blood
  • Carbamazepine / pharmacokinetics*
  • Delayed-Action Preparations
  • Drug Interactions
  • Half-Life
  • Humans
  • Intestinal Absorption
  • Male
  • Middle Aged
  • Omeprazole / pharmacology*

Substances

  • Anti-Ulcer Agents
  • Anticonvulsants
  • Delayed-Action Preparations
  • Carbamazepine
  • Omeprazole