The Phylogeography of Y Chromosome Binary Haplotypes and the Origins of Modern Human Populations

Ann Hum Genet. 2001 Jan;65(Pt 1):43-62. doi: 10.1046/j.1469-1809.2001.6510043.x.

Abstract

Although molecular genetic evidence continues to accumulate that is consistent with a recent common African ancestry of modern humans, its ability to illuminate regional histories remains incomplete. A set of unique event polymorphisms associated with the non-recombining portion of the Y-chromosome (NRY) addresses this issue by providing evidence concerning successful migrations originating from Africa, which can be interpreted as subsequent colonizations, differentiations and migrations overlaid upon previous population ranges. A total of 205 markers identified by denaturing high performance liquid chromatography (DHPLC), together with 13 taken from the literature, were used to construct a parsimonious genealogy. Ancestral allelic states were deduced from orthologous great ape sequences. A total of 131 unique haplotypes were defined which trace the microevolutionary trajectory of global modern human genetic diversification. The genealogy provides a detailed phylogeographic portrait of contemporary global population structure that is emblematic of human origins, divergence and population history that is consistent with climatic, paleoanthropological and other genetic knowledge.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Africa
  • Alleles
  • Biological Evolution*
  • Chromatography, High Pressure Liquid
  • DNA, Mitochondrial / metabolism
  • Emigration and Immigration
  • Evolution, Molecular*
  • Geography
  • Haplotypes
  • Humans
  • Male
  • Models, Genetic
  • Phylogeny
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Sequence Analysis, DNA
  • Y Chromosome*

Substances

  • DNA, Mitochondrial