Genetical genomics: the added value from segregation

Trends Genet. 2001 Jul;17(7):388-91. doi: 10.1016/s0168-9525(01)02310-1.


The recent successes of genome-wide expression profiling in biology tend to overlook the power of genetics. We here propose a merger of genomics and genetics into 'genetical genomics'. This involves expression profiling and marker-based fingerprinting of each individual of a segregating population, and exploits all the statistical tools used in the analysis of quantitative trait loci. Genetical genomics will combine the power of two different worlds in a way that is likely to become instrumental in the further unravelling of metabolic, regulatory and developmental pathways.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Mapping / methods*
  • Chromosome Segregation / genetics
  • DNA Fingerprinting / methods
  • DNA, Complementary / genetics
  • Gene Expression Profiling / methods*
  • Genetic Variation / genetics
  • Genome, Human
  • Genomics / methods*
  • Humans
  • Oligonucleotide Array Sequence Analysis
  • Plants / genetics
  • Quantitative Trait, Heritable*


  • DNA, Complementary