Abstract
We describe a child with aggressive and protracted Kawasaki disease with coronary aneurysms, myocarditis, pericarditis and valvular insufficiency, despite repeated administration of intravenous immunoglobulin. After a transient response to pulse corticosteroids, his disease ultimately subsided with combination therapy with pulse and high dosage corticosteroids and cyclosporin A. Aggressive immunosuppressive therapy with high dosage corticosteroids and cyclosporin A may be beneficial in patients with refractory Kawasaki disease.
MeSH terms
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Anti-Inflammatory Agents / therapeutic use*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Aspirin / therapeutic use
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Child, Preschool
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Cyclosporine / therapeutic use*
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Drug Therapy, Combination
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Humans
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Immunoglobulins, Intravenous / therapeutic use
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Immunosuppressive Agents / therapeutic use*
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Male
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Methylprednisolone / therapeutic use*
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Mucocutaneous Lymph Node Syndrome / drug therapy*
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Mucocutaneous Lymph Node Syndrome / immunology
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Recurrence
Substances
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Immunoglobulins, Intravenous
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Immunosuppressive Agents
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Cyclosporine
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Aspirin
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Methylprednisolone