Reversible central nervous system dysfunction in folate deficiency

J Neurol Sci. 1975 May;25(1):93-8. doi: 10.1016/0022-510x(75)90189-6.


An epileptic patient on chronic anticonvulsant drug therapy is described, in whom anaemia and neurological abnormalities including progressive dementia, bilateral pyramidal tract signs, incontinence and ataxia developed. Vitamin B12 serum levels and absorption were normal, but serum folic acid levels were low. Both the neurological disturbances and anaemia resolved following oral folic acid administration. This sequence of events in our patient suggests a cause and effect relationship between the folate deficiency and the coexistent, transient neurological syndrome.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anemia, Megaloblastic / drug therapy
  • Anemia, Megaloblastic / etiology
  • Anticonvulsants / adverse effects
  • Epilepsy / drug therapy
  • Fecal Incontinence / etiology
  • Female
  • Folic Acid / therapeutic use
  • Folic Acid Deficiency / blood
  • Folic Acid Deficiency / complications*
  • Humans
  • Mental Disorders / drug therapy
  • Mental Disorders / etiology*
  • Movement Disorders / drug therapy
  • Movement Disorders / etiology*
  • Nutrition Disorders / complications
  • Remission, Spontaneous
  • Urinary Incontinence / etiology


  • Anticonvulsants
  • Folic Acid