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. 2001 May 25;756(1-2):189-98.
doi: 10.1016/s0378-4347(01)00108-6.

Structure and Properties of Ovalbumin


Structure and Properties of Ovalbumin

J A Huntington et al. J Chromatogr B Biomed Sci Appl. .


Ovalbumin is a protein of unknown function found in large quantities in avian egg-white. Surprisingly, ovalbumin belongs to the serpin family although it lacks any protease inhibitory activity. We review here what is known about the amino acid sequence, post-translational modifications and tertiary structure of ovalbumin. The properties of ovalbumin are discussed in relation to their possible functional significance. These include reasons for failure of ovalbumin to undergo a typical serpin conformational change involving the reactive centre loop, which explains why ovalbumin is not a protease inhibitor, and also the natural conversion of ovalbumin to the more stable "S" form.

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