Perfluorodecalin-induced intravitreal inflammation

Retina. 2001;21(3):247-51. doi: 10.1097/00006982-200106000-00009.


Objective: To report an unusual case of intravitreal inflammation in a human eye caused by the presence of residual perfluorodecalin in a case of giant retinal tear and retinal detachment.

Methods: The posterior capsule of the lens, which was infiltrated with deposits, was collected during surgery. The specimen was stained with hematoxylin and eosin, with periodic acid-Schiff, and for melanin. Part of it was examined with electron microscopy. Immunohistochemical staining was performed to demonstrate CD68 antigens, cytokeratin, and glial fibrillary acid protein.

Results: Vacuolated macrophages and retinal pigment epithelial cells infiltrated the posterior capsule. Electron microscopy showed the presence of membrane-lined vacuoles within the macrophages. A monolayer of epithelial cells covered the cellular infiltration.

Conclusion: Residual perfluorodecalin can induce an intraocular chronic macrophage response.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, CD / metabolism
  • Antigens, Differentiation, Myelomonocytic / metabolism
  • Cryosurgery
  • Endophthalmitis / chemically induced*
  • Endophthalmitis / pathology
  • Eye Diseases / chemically induced
  • Fluorocarbons / adverse effects*
  • Glial Fibrillary Acidic Protein / metabolism
  • Humans
  • Immunoenzyme Techniques
  • Keratins / metabolism
  • Lens Capsule, Crystalline / metabolism
  • Lens Capsule, Crystalline / pathology
  • Macrophages / metabolism
  • Macrophages / ultrastructure
  • Male
  • Phacoemulsification
  • Reoperation
  • Retinal Detachment / etiology
  • Retinal Detachment / surgery
  • Retinal Perforations / complications
  • Retinal Perforations / surgery
  • Scleral Buckling
  • Vitrectomy
  • Vitreous Body / drug effects*
  • Vitreous Body / pathology


  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • CD68 antigen, human
  • Fluorocarbons
  • Glial Fibrillary Acidic Protein
  • perfluorodecalin
  • Keratins