ABC transporter-mediated uptake of iron, siderophores, heme and vitamin B12

Res Microbiol. Apr-May 2001;152(3-4):291-301. doi: 10.1016/s0923-2508(01)01200-1.

Abstract

Microbes have developed a number of different strategies to utilize iron, which is a vital element for most organisms but not always readily available from the environment. Based on experimental studies and sequence analysis data, this article gives a short overview of ABC transporters related to iron uptake: components of three distinct families mediate the translocation of iron, siderophores, heme and vitamin B12 across the cytoplasmic membrane of bacteria.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / chemistry
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism*
  • Cell Membrane / metabolism
  • Conserved Sequence
  • Escherichia coli / genetics
  • Escherichia coli / metabolism
  • Ferric Compounds / metabolism
  • Heme / metabolism*
  • Inosine Monophosphate / metabolism
  • Iron / metabolism*
  • Phylogeny
  • Siderophores / metabolism*
  • Substrate Specificity
  • Vitamin B 12 / metabolism*

Substances

  • ATP-Binding Cassette Transporters
  • Ferric Compounds
  • Siderophores
  • Inosine Monophosphate
  • Heme
  • Iron
  • Vitamin B 12