Somamides A and B, two new depsipeptide analogues of dolastatin 13 from a Fijian cyanobacterial assemblage of Lyngbya majuscula and Schizothrix species

J Nat Prod. 2001 Jun;64(6):716-9. doi: 10.1021/np000634j.

Abstract

Somamides A (1) and B (2) were isolated from assemblages of the marine cyanobacteria Lyngbya majusculaand Schizothrix sp. from the Fijian Islands. These new depsipeptides are analogous in structure to the cyanobacterial metabolite symplostatin 2 (4) as well as dolastatin 13 (3), originally isolated from Dolabella auricularia, further demonstrating the cyanobacterial origin of the dolastatins.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acids / chemistry
  • Cyanobacteria / chemistry*
  • Depsipeptides*
  • Fiji
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Oligopeptides / chemistry
  • Oligopeptides / isolation & purification*
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Spectrometry, Mass, Fast Atom Bombardment

Substances

  • Amino Acids
  • Depsipeptides
  • Oligopeptides
  • Peptides, Cyclic
  • dolastatin 13
  • somamide A
  • somamide B