Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family

Clin Lab Haematol. 2001 Feb;23(1):53-5. doi: 10.1046/j.1365-2257.2001.00349.x.


A Chinese family with concurrent hereditary spherocytosis (HS) and haemoglobin (Hb) Q-Thailand is described. The Hb Q-Thailand mutation was found on the remaining alpha1 globin gene on a chromosome 16 containing the (-alpha 4.2) deletion. Active haemolysis in members of this family is segregated with the HS phenotype, and the Hb Q-Thailand in the heterozygous state does not seem to show any modulating effect on HS.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Hemolytic, Congenital / etiology
  • Anemia, Hemolytic, Congenital / genetics
  • China
  • Family Health
  • Female
  • Genotype
  • Hemoglobins, Abnormal / genetics*
  • Heterozygote
  • Humans
  • Nuclear Family
  • Osmotic Fragility / genetics
  • Pedigree
  • Phenotype
  • Spherocytosis, Hereditary / blood
  • Spherocytosis, Hereditary / complications
  • Spherocytosis, Hereditary / genetics*


  • Hemoglobins, Abnormal
  • hemoglobin Q Thailand