Helicobacter pylori: has the killer escaped from the institution? A possible cause of increased stomach cancer in a population with intellectual disability

J Intellect Disabil Res. 2001 Jun;45(Pt 3):219-25. doi: 10.1046/j.1365-2788.2001.00302.x.


Advancing knowledge of the existence of Helicobacter pylori and its association with gastrointestinal tract malignancy, and previous research showing higher-than-expected gastrointestinal tract malignancy in institutionalized adults with intellectual disability (ID) prompted a review of all deaths as a result of cancer in the Stoke Park group of hospitals for people with ID between 1946 and 1996. A 50-year, retrospective case note analysis of all deaths from cancer in an institution for people with ID was undertaken. Death from stomach cancer accounted for up to 48% of all cancer deaths. A further 25 residents had died of perforated stomach ulcers. The higher proportion of deaths specifically caused by stomach cancer in a population with ID has not been noted previously. It is postulated that the high levels of H. pylori infection found in institutionalized populations may be instrumental in this higher mortality rate and that the closure of the institutions without evaluation of H. pylori status transfers the problem unresolved to the community. Existing guidelines for the screening and eradication of H. pylori developed for the general population are inadequate when applied to people with ID, and therefore, the value of population screening and mass eradication programmes is explored.

MeSH terms

  • Cause of Death
  • Female
  • Helicobacter Infections / microbiology
  • Helicobacter Infections / mortality*
  • Helicobacter pylori*
  • Hospital Mortality
  • Humans
  • Institutionalization / statistics & numerical data*
  • Intellectual Disability / mortality*
  • Male
  • Peptic Ulcer Perforation / mortality
  • Retrospective Studies
  • Stomach Neoplasms / microbiology
  • Stomach Neoplasms / mortality*
  • United Kingdom / epidemiology