Effect of a high monounsaturated fatty acid diet on blood pressure and glucose metabolism in women with gestational diabetes mellitus

Eur J Clin Nutr. 2001 Jun;55(6):436-43. doi: 10.1038/sj.ejcn.1601193.


Objective: The effect of a diet rich in monounsaturated fatty acids (MUFA) on blood pressure, glycemic control, lipids and insulin sensitivity was evaluated in women with gestational diabetes mellitus.

Design and methods: A randomized, unpaired diet intervention was performed in 27 women with gestational diabetes mellitus in an outpatient clinic. After randomization the women received either a high-carbohydrate diet (H-CHO) or a high-MUFA diet (H-MUFA) from the 33rd gestational week of pregnancy. Outcome measures were 24 h ambulatory blood pressure, blood lipids, glycemic control and insulin sensitivity estimated by an intravenous glucose tolerance test.

Results: The 24 h diastolic blood pressure increased more in the H-CHO group than in the H-MUFA group (P<0.04).

Conclusions: After 5 weeks of treatment with a MUFA-enriched diet, no increase in 24 h diastolic blood pressure and no adverse effects on blood lipids were seen. The favorable effect on the blood pressure by the MUFA diet is a possible non-medication treatment. The H-MUFA diet had no advantage to the H-CHO diet in ameliorating the decline of insulin sensitivity in third term of pregnancy in GDM.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism*
  • Blood Pressure / drug effects*
  • Diabetes, Gestational / blood
  • Diabetes, Gestational / diet therapy
  • Diabetes, Gestational / physiopathology*
  • Dietary Carbohydrates / administration & dosage
  • Dietary Carbohydrates / pharmacology*
  • Fatty Acids, Monounsaturated / administration & dosage
  • Fatty Acids, Monounsaturated / pharmacology*
  • Female
  • Glucose Tolerance Test
  • Humans
  • Insulin / blood
  • Insulin / metabolism
  • Lipid Metabolism
  • Pregnancy


  • Blood Glucose
  • Dietary Carbohydrates
  • Fatty Acids, Monounsaturated
  • Insulin