Differential expression of metallopanstimulin/S27 ribosomal protein in hepatic regeneration and neoplasia

Cancer Detect Prev. 2001;25(3):231-6.


We have previously shown that human metallopanstimulin-1 (MPS-1) is a ubiquitous 9.4-kd multifunctional ribosomal S27/nuclear "zinc finger" protein that is expressed at high levels in a wide variety of actively proliferating cells and tumor tissues. In this study, we examined the expression of MPS-1 in chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Tissue samples were obtained at the time of tumor resection, needle biopsy, or liver transplantation. MPS- 1 was studied by immunohistochemistry by use of specific antibodies to the N-terminus of MPS-1 in a biotin/streptavidin-amplified system. In chronic hepatitis, hepatocytes had very weak MPS-1 immunostaining. In contrast, hepatocytes in regenerating cirrhotic nodules stained strongly for MPS-1. In well-differentiated hepatocellular carcinoma, MPS-1 presence was intense at the periphery of the malignant nodule. In poorly differentiated hepatocellular carcinoma, MPS-1 presence was notably intense in malignant hepatocytes invading the septal tissues, in close contact with neovascular structures. These results suggest that MPS-1 may be involved in both progression toward malignancy in regenerating cirrhotic nodules and in subsequent steps of hepatocarcinogenesis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antibodies / analysis
  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / pathology
  • Cell Differentiation
  • Cell Transformation, Neoplastic*
  • Disease Progression
  • Gene Expression Regulation, Neoplastic*
  • Hepatitis, Chronic / genetics*
  • Hepatitis, Chronic / pathology
  • Hepatocytes / immunology
  • Hepatocytes / physiology
  • Humans
  • Immunohistochemistry
  • Liver Cirrhosis / genetics*
  • Liver Cirrhosis / pathology
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / pathology
  • Liver Regeneration / genetics
  • Liver Regeneration / physiology
  • Metalloproteins / biosynthesis*
  • Nuclear Proteins / biosynthesis*
  • RNA-Binding Proteins
  • Ribosomal Proteins / biosynthesis*


  • Antibodies
  • Metalloproteins
  • Nuclear Proteins
  • RNA-Binding Proteins
  • RPS27 protein, human
  • Ribosomal Proteins
  • ribosomal protein S27a