Biphenyls as surrogates of the steroidal backbone. Part 1: synthesis and estrogen receptor affinity of an original series of polysubstituted biphenyls

Bioorg Med Chem Lett. 2001 Jul 9;11(13):1709-12. doi: 10.1016/s0960-894x(01)00267-0.


In the course of a programme aimed at discovering new ligands of the estrogen receptor, we explored a series of substituted biphenyls. Their synthesis and binding affinity are described.

MeSH terms

  • Biphenyl Compounds / chemical synthesis*
  • Biphenyl Compounds / pharmacology*
  • Estrogen Receptor alpha
  • Humans
  • Receptors, Estrogen / drug effects*
  • Recombinant Proteins / drug effects
  • Steroids / chemistry*


  • Biphenyl Compounds
  • Estrogen Receptor alpha
  • Receptors, Estrogen
  • Recombinant Proteins
  • Steroids