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, 11 (13), 1737-40

Isoindolines: A New Series of Potent and Selective endothelin-A Receptor Antagonists

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Isoindolines: A New Series of Potent and Selective endothelin-A Receptor Antagonists

P J Kukkola et al. Bioorg Med Chem Lett.

Abstract

1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET(A) selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure-activity relationships for both the trans and the cis series of isoindolines are discussed.

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