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. 2001 Apr;54(4):340-8.
doi: 10.7164/antibiotics.54.340.

New type II manumycins produced by Streptomyces nodosus ssp. asukaensis and their biosynthesis

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Free article

New type II manumycins produced by Streptomyces nodosus ssp. asukaensis and their biosynthesis

Y Hu et al. J Antibiot (Tokyo). 2001 Apr.
Free article

Abstract

Five new type II manumycins, containing the hydroxyquinol mC7N unit, asukamycins A-II, B-II, C-II, D-II, E-II, were discovered in cultures of Streptomyces nodosus ssp. asukaensis. The biosynthetic origin of the type II manumycins from the type I compounds, containing an epoxyquinol mC7N unit, was deduced from the time course of production and proven by preparing [7'-13C]asukamycin A and demonstrating its incorporation into asukamycin A-II.

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