Resveratrol, a Tumor-Suppressive Compound From Grapes, Induces Apoptosis via a Novel Mitochondrial Pathway Controlled by Bcl-2

FASEB J. 2001 Jul;15(9):1613-5. doi: 10.1096/fj.00-0675fje.

MeSH terms

  • Anticarcinogenic Agents / pharmacology
  • Apoptosis Inducing Factor
  • Apoptosis*
  • Biological Transport / drug effects
  • Caspase 2
  • Caspase 3
  • Caspase 6
  • Caspase 9
  • Caspases / metabolism
  • Cytochrome c Group / metabolism
  • DNA / drug effects
  • DNA / metabolism
  • Enzyme Activation
  • Flavoproteins / metabolism
  • Humans
  • Membrane Proteins / metabolism
  • Mitochondria / metabolism*
  • Proto-Oncogene Proteins c-bcl-2 / metabolism*
  • Reactive Oxygen Species / metabolism
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Member 25
  • Resveratrol
  • Rosales / chemistry
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Stilbenes / pharmacology*
  • Tumor Cells, Cultured

Substances

  • Anticarcinogenic Agents
  • Apoptosis Inducing Factor
  • Cytochrome c Group
  • Flavoproteins
  • Membrane Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Reactive Oxygen Species
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Member 25
  • Stilbenes
  • TNFRSF25 protein, human
  • DNA
  • CASP3 protein, human
  • CASP6 protein, human
  • CASP9 protein, human
  • Caspase 2
  • Caspase 3
  • Caspase 6
  • Caspase 9
  • Caspases
  • Resveratrol