Up-regulation of the fibrogenic cytokine TGF-beta1 by oxysterols: a mechanistic link between cholesterol and atherosclerosis

FASEB J. 2001 Jul;15(9):1619-21. doi: 10.1096/fj.00-0668fje.
No abstract available

MeSH terms

  • Animals
  • Arteriosclerosis / metabolism*
  • Cell Survival / drug effects
  • Cells, Cultured
  • Cholesterol / pharmacology*
  • Ketocholesterols / pharmacology*
  • Macrophages / drug effects*
  • Macrophages / metabolism
  • Mice
  • RNA, Messenger / drug effects
  • RNA, Messenger / metabolism
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / metabolism*
  • Transforming Growth Factor beta1
  • Up-Regulation

Substances

  • Ketocholesterols
  • RNA, Messenger
  • Tgfb1 protein, mouse
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1
  • Cholesterol
  • 7-ketocholesterol