The early steps of neural crest development

Mech Dev. 2001 Jul;105(1-2):27-35. doi: 10.1016/s0925-4773(01)00394-x.


The neural crest is an intriguing cell population that gives rise to many derivatives which are all generated far from their final destinations. From its induction to the delamination of the cells, multiple signalling pathways converge to regulate the expression of effector genes, the products of which endow the cells with invasive and migratory properties reminiscent of those displayed by malignant cells in tumours. As such, the neural crest constitutes an excellent model to study cell migration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / physiology
  • Cadherins / physiology
  • Cell Adhesion
  • Cell Movement
  • Drosophila
  • Epithelial Cells / metabolism
  • Humans
  • Mesoderm / metabolism
  • Models, Biological
  • Neural Crest / embryology*
  • Neural Crest / physiology*
  • Phenotype
  • Signal Transduction
  • Xenopus
  • Zebrafish


  • Bone Morphogenetic Proteins
  • Cadherins