Pattern formation in the lateral line of zebrafish

Mech Dev. 2001 Jul;105(1-2):69-77. doi: 10.1016/s0925-4773(01)00382-3.

Abstract

The lateral line of fish and amphibians is a sensory system that comprises a number of individual sense organs, the neuromasts, arranged in a defined pattern on the surface of the body. A conspicuous part of the system is a line of organs that extends along each flank (and which gave the system its name). At the end of zebrafish embryogenesis, this line comprises 7-8 neuromasts regularly spaced between the ear and the tip of the tail. The neuromasts are deposited by a migrating primordium that originates from the otic region. Here, we follow the development of this pattern and show that heterogeneities within the migrating primordium prefigure neuromast formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Lineage
  • Cell Movement
  • Cell Nucleus / metabolism
  • Dextrans / pharmacology
  • Fluorescein / pharmacology
  • Fluorescent Dyes / pharmacology
  • Gene Expression Regulation, Developmental*
  • Hair Cells, Auditory / metabolism
  • In Situ Hybridization
  • Microscopy, Video
  • Mitosis
  • Neurons / physiology*
  • Time Factors
  • Ultraviolet Rays
  • Zebrafish

Substances

  • Dextrans
  • Fluorescent Dyes
  • Fluorescein