Co-localization of KLF6 and KLF4 with pregnancy-specific glycoproteins during human placenta development

Mech Dev. 2001 Jul;105(1-2):185-9. doi: 10.1016/s0925-4773(01)00391-4.


Pregnancy-specific glycoproteins (PSGs) are major placental proteins essential for the maintenance of normal gestation. However, little is known about their gene expression regulation during placentation. It was previously demonstrated that the human core promoter binding protein recently renamed Krüppel-like factor (KLF) 6 binds to a highly conserved sequence within the PSG promoters and is mainly expressed in human term placenta. Here, we determined the expression pattern of the 13 other KLFs during human placental development. We demonstrate that eight KLFs exhibit specific expression patterns in human placental tissues and membranes, in favor of a functional cooperation of specific KLFs during placentation. In addition, we demonstrate that KLF6, KLF4 and PSG proteins are co-expressed in same cell types of placental villi and membranes. This experimental evidence further strengthens the potential cross talk of both transcription factors for PSG gene regulation in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA-Binding Proteins / biosynthesis*
  • Glycoproteins / biosynthesis
  • Glycoproteins / metabolism
  • Humans
  • In Situ Hybridization
  • Kruppel-Like Factor 6
  • Kruppel-Like Transcription Factors
  • Placenta / metabolism*
  • Pregnancy Proteins / biosynthesis
  • Pregnancy-Specific beta 1-Glycoproteins*
  • Protein Binding
  • Proto-Oncogene Proteins*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Trans-Activators / biosynthesis*
  • Transcription Factors*


  • DNA-Binding Proteins
  • GKLF protein
  • Glycoproteins
  • KLF6 protein, human
  • Kruppel-Like Factor 6
  • Kruppel-Like Transcription Factors
  • PSG5 protein, human
  • Pregnancy Proteins
  • Pregnancy-Specific beta 1-Glycoproteins
  • Proto-Oncogene Proteins
  • Trans-Activators
  • Transcription Factors
  • erythroid Kruppel-like factor