Ig heavy-chain gene revision: leaping towards autoimmunity

Trends Immunol. 2001 Jul;22(7):400-5. doi: 10.1016/s1471-4906(01)01953-6.


B cells can revise their antigen receptors outside the confines of the bone marrow by secondary Ig gene rearrangements. Although the initial motivation to perform these revisions might be to silence a self-reactive specificity, those B cells that reinitiate the recombination process can perform a series of "leaping" rearrangements and inadvertently shift their receptor specificity towards autoimmunity. Heavy-chain receptor revision, coupled with other atypical rearrangements, might contribute to autoantibody production in systemic lupus erythematosus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Autoimmunity / genetics
  • Autoimmunity / immunology*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / immunology
  • Gene Rearrangement, B-Lymphocyte, Heavy Chain*
  • Genes, Immunoglobulin
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / immunology
  • Humans
  • Immunoglobulin Heavy Chains / genetics*
  • Immunoglobulin Heavy Chains / immunology
  • Nuclear Proteins
  • Receptors, Antigen, B-Cell / genetics
  • Receptors, Antigen, B-Cell / immunology


  • DNA-Binding Proteins
  • Homeodomain Proteins
  • Immunoglobulin Heavy Chains
  • Nuclear Proteins
  • RAG2 protein, human
  • Receptors, Antigen, B-Cell
  • V(D)J recombination activating protein 2
  • RAG-1 protein